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Inflammation and Autoimmune Disease Models

Basic Information

　　Inflammation is a physiological response process of the immune system to injury and infection. During this process, signals are sent to immune cells to promote the healing and repair of damaged tissues and protect the body from infectious factors such as viruses and bacteria. However, prolonged or excessive activation of inflammation can also be detrimental to the body and lead to pathogenicity. Chronic inflammation is a major cause of various diseases, such as Inflammatory Bowel Disease (IBD: Crohn's disease, ulcerative colitis, etc). Psoriasis and chronic obstructive pulmonary disease (COPD)、Psoriasis, asthma, etc.
　　Autoimmune diseases refer to a series of disorders where the immune system mistakenly attacks its own tissues and organs. This autoimmune response typically involves adaptive immune dysregulation against self-antigens, often mediated by B lymphocytes and T lymphocytes. The immune response of the body to foreign antigens typically results in their clearance. However, when there is an immune response against self-cell or tissue antigens, the body's own cells or tissues are not easily eliminated by the effector cells of the immune system and instead continuously come under attack. As a result, the body enters a diseased state. Common autoimmune diseases include systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), etc.
　　With years of experience in constructing and validating numerous animal models, Jennio can provide stable animal models for inflammation and autoimmune diseases, which provides powerful support for researches in the field of inflammation and autoimmune diseases.

Services We Provide

　　①Stable animal model (including but not limited to):
　　Animal model of Crohn's disease induced by trinitro-benzene-sulfonic acid(TNBS)
　　Animal model of ulcerative colitis induced by Dextran Sulfate Sodium Salt (DSS)
　　Psoriasis animal model induced by imiquimod
　　Animal model of chronic obstructive pulmonary disease (COPD) induced by a combination of lipopolysaccharide (LPS) and smoke exposure
　　Animal model of spontaneous systemic lupus erythematosus (SLE).
　　Chemical-induced animal model of systemic lupus erythematosus (SLE)
　　Adjuvant-induced arthritis animal model
　　Collagen-induced arthritis animal model
　　Collagen antibody-induced arthritis animal model

　　②Professional detection system (including but not limited to):
　　Histopathological examination
　　Immumohistochemical staining
　　Professional clinical scoring.
　　Cytokine/chemokine detection
　　Flow cytometry analysis
　　Nephritis assessment
　　Anti-DNA antibody quantification（ELISA、western blot）.
　　Lymphocyte proliferation assessment.
　　Pharmacokinetic testing

Procedure of Services

Features

　　①With years of experience in constructing animal models for inflammation and autoimmune diseases, we can provide stable animal models for in vivo drug efficacy studies.
　　②Jennio has professional research teams with members having years of GLP preclinical trial experiences, and provides high levels of drug efficacy research based on the standardized professional operations and strict quality control management systems.
　　③Jennio has  well-equipped testing platforms that can meet various clinical indicator testing requirements.
　　④Jennio has experienced preclinical research experts who have collaborated with several well-known domestic pharmaceutical companies to complete preclinical efficacy testing and drug clinical trial application, providing customers with strong support for drug research and development.

Representative Case

Our Laboratory