CRO服务

Non-GLP Pharmacology and Toxicology Research

Basic Information

　　Before clinical trials, it is essential to study the potential toxicity of candidate drugs in order to identify any adverse effects. The purpose of preclinical safety assessment is generally to determine the toxic effects on target organs, dose dependency, the relationship between compound exposure, and to identify potential reversibility. All these data will be used to establish a safe starting dose for clinical trials and determine parameters for monitoring potential adverse reactions during clinical monitoring. However, if conducting large-scale toxicity and safety studies in GLP (Good Laboratory Practice) facilities without initial knowledge of the effective dose and safety dose of the test substance may lead to dose adjustments and repetition of subsequent efficacy tests, which may result in increased risks and significant escalation of research costs.
　　Jennio has pharmacology and toxicology experts with years of experience in GLP facilities for preclinical projects. We can design tailored toxicity and safety studies for clients in the early stages of identifying effective drug doses. These studies can provide preliminary characterization of the drug safety dose and potential toxic target organs, which provides data support for subsequent preclinical safety research.

Services We Provide

　　①We provide experimental methods for various routes of drug administration.

　　Our professional research team is proficient in various standardized drug administration methods, which includes but not limited to oral administration, intravenous injection, inhalation, nasal delivery, tracheal administration, intramuscular injection, subcutaneous administration, ocular instillation, intravaginal delivery, intraduodental administration, intrathecal/intracerebral/epidural, and intraperitoneal routes.
　　②We provide GLP-compliant toxicity testing, including but not limited to:
　　Acute Toxicity Testing
　　Toxicity Testing for Long-Term Administration
　　Hemolytic Testing
　　Tumorigenic/Carcinogenicity Testing
　　Genetic Toxicity Testing
　　③Professional detection system (including but not limited to):
　　Histopathological examination
　　Hematological Examination (Hematology/Blood Biochemistry)
　　Clinical Toxicity Assessment

Procedure of Services

Features

　　①We have experienced preclinical pharmacology and toxicology experts, pathology experts, and veterinarians who can conduct standardized toxicity research experiments.
　　②Jennio has professional research teams with members having years of GLP preclinical trial experiences, and provides high levels of drug efficacy research based on the standardized professional operations and strict quality control management systems.
　　③Jennio has  well-equipped testing platforms that can meet various clinical indicator testing requirements.
　　④Jennio has strictly standardized breeding environments for mice, rats, guinea pigs, and rabbits, which can meet the toxicity research needs of various animal species.

Representative Case

Our Laboratory