CRO服务

Hepatitis B Virus Model

Basic Information

　　Hepatitis B is a global public health disease caused by infection with the hepatitis B virus (HBV). HBV is a non-cytopathic enveloped virus with a circular double-stranded DNA genome. HBV infection can lead to acute or chronic inflammatory liver diseases. In addition, chronic hepatitis B virus (HBV) infection remains a major cause of liver cirrhosis and hepatocellular carcinoma (HCC). Despite the availability of effective vaccines, the proportion of existing HBV carriers still remains high, and vaccination does not treat individuals who are already diagnosed with HBV infection. Therefore, stable HBV animal models are crucial for studying the mechanisms of HBV and developing novel therapies.
　　With years of experience in constructing and validating numerous animal models, Jennio can provide stable HBV animal models, offering support for researches in the field of HBV.

Services We Provide

　　①Stable animal models (including but not limited to):
　　HBV model induced by Hydrodynamic injection (HDI ) injection.
　　HBV model induced by AAV/HBV-1.3 virus infection.
　　②Professional detection system (including but not limited to):
　　Serum/Plasma HBV DNA detection
　　Serum/Plasma HBsAg、HBeAg、HBsAb detection
　　Serum alanine aminotransferase (ALT) detection
　　Immumohistochemical staining
　　Histopathological examination
　　Close clinical observation and weight monitoring

Procedure of Services

Features

　　①Jennio has years of experience in constructing HBV animal models and can provide customers with stable animal models for in vivo drug efficacy studies.
　　②Jennio has professional research teams with members having years of GLP preclinical trial experiences, and provides high levels of drug efficacy research based on the standardized professional operations and strict quality control management systems.
　　③Jennio has  well-equipped testing platforms that can meet various clinical indicator testing requirements.
　　④Jennio has experienced preclinical research experts who have collaborated with several well-known domestic pharmaceutical companies to complete preclinical efficacy testing and drug clinical trial application, providing customers with strong support for drug research and development.

Representative Case

Our Laboratory