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Cell derived xenograft mouse model

Basic Information

　　The xenograft tumor model derived from human cell lines (CDX) has been widely used as a milestone model in the development of anti-tumor drugs. It has been extensively applied for preclinical drug efficacy testing, PK/PD correlation studies and combination therapy. When implanted human tumor cells into immunodeficient mice, it can form tumor tissues in the mice, which allows the study of novel anti-tumor drugs and its underlying mechanisms in CDX model.
　　Jennio has years of experience in constructing CDX models and has established an extensive cell bank. The bank contains over 1000 different tumor cell lines from various tumor types, which have been identified through STR profiling, which provides strong support for oncology researches.

 Services We Provide

　　①Stable animal model (including but not limited to)
　　CDX model of lung cancer
　　CDX model of gastric carcinoma
　　CDX model of hepatocellular carcinoma
　　CDX model of breast cancer
　　CDX model of cervical cancer
　　CDX model of esophagus cancer
　　CDX model of Pancreatic cancer
　　CDX model of nasopharynx cancer
　　CDX model of bladder cancer
　　CDX model of colorectal cancer
　　②Professional detection system (including but not limited to)
　　Histopathological examination
　　Immumohistochemical staining
　　Immunofluorescent staining
　　STR identification.
　　Evaluation of drug efficacy
　　Cytokine/chemokine detection
　　Flow cytometry analysis
　　MTT/CCK8 assay

Procedure of Services

Features

　　①Jennio possesses an extensive cell bank with over 1000 tumor cell lines that have been identified through STR profiling and maintained according to GMP standards.
　　②Jennio has years of experience in constructing CDX animal models and can provide customers with stable animal models for in vivo drug efficacy research.
　　③Jennio has professional research teams with members having years of GLP preclinical trial experiences, and provides high levels of drug efficacy research based on the standardized professional operations and strict quality control management systems.
　　④Jennio has  well-equipped testing platforms that can meet various clinical indicator testing requirements.
　　⑤Jennio has experienced preclinical research experts who have collaborated with several well-known domestic pharmaceutical companies to complete preclinical efficacy testing and drug clinical trial application, providing customers with strong support for drug research and development.

Representative Case

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